Cancer Risk after Cyclophosphamide Treatment in Idiopathic Membranous Nephropathy

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Cancer risk after cyclophosphamide treatment in idiopathic membranous nephropathy.

BACKGROUND AND OBJECTIVES Cyclophosphamide treatment improves renal survival in patients with idiopathic membranous nephropathy. However, use of cyclophosphamide is associated with cancer. The incidence of malignancies in patients with idiopathic membranous nephropathy was evaluated, and the cancer risk associated with cyclophosphamide use was estimated. DESIGN, SETTING, PARTICIPANTS, & MEASU...

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Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently being explored for this disease including Ri...

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Balancing cancer risk and efficacy of using cyclophosphamide to treat idiopathic membranous nephropathy.

In 1950, Coons and Kaplan described a technique for labeling antibodies with fluorescent probes to detect antigens in tissue (1). Using this technique, it was possible to classify glomerulopathies according to their appearance by immunofluorescence staining. One distinct entity, membranous nephropathy (MN), was highly characterized by granular deposits of IgG and, frequently, C3 along the glome...

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ژورنال

عنوان ژورنال: Clinical Journal of the American Society of Nephrology

سال: 2014

ISSN: 1555-9041,1555-905X

DOI: 10.2215/cjn.08880813